Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization
نویسندگان
چکیده
A synthesis to access rarely described 3-amino-5-fluoroalkylfurans has been developed by cyclization of easily accessible fluorovinamides. This method is rapid and simple affords the desired furans as hydrochloride salts in quantitative or nearly yields. It compatible with four different fluorinated groups (-CF3, -CF2CF3, -CHF2, -CF2Cl) a wide range substituents on amine.
منابع مشابه
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c01672